HMGA1
MIM.600701 6p21
Pathology
6p21 (HMGA1) rearrangements (21.3%) in pulmonary chondroid hamartoma (#14621194#)
- t(6;14)(p21.3;q24) with RAD51L1 at 14q24 (#11978964#)
6p21 amplification
- malignant ectomesenchymoma (MEM) (#18043289#)
Animal models
Haploinsufficiency of the Hmga1 gene causes cardiac hypertrophy and myelo-lymphoproliferative disorders in mice (#16510570#)
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice (#15924147#)
References
Floris G, Debiec-Rychter M, Wozniak A, Magrini E, Manfioletti G, De Wever I, Tallini G, Sciot R. Malignant ectomesenchymoma: genetic profile reflects rhabdomyosarcomatous differentiation. Diagn Mol Pathol. 2007 Dec;16(4):243-8. PMID: #18043289#
Fedele M, Battista S, Manfioletti G, Croce CM, Giancotti V, Fusco A. Role of the high mobility group A proteins in human lipomas. Carcinogenesis. 2001 Oct;22(10):1583-91. PMID: #11576996#
Wood, L. J.; Mukherjee, M.; Dolde, C. E.; Xu, Y.; Maher, J. F.; Bunton, T. E.; Williams, J. B.; Resar, L. M. S. : HMG-I/Y, a new c-Myc target gene and potential oncogene. Molec. Cell Biol. 20: 5490-5502, 2000. PubMed ID : #10891489#
Tallini G, Dal Cin P. HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors. Adv Anat Pathol. 1999 Sep;6(5):237-46. PMID: #10472377#
Kazmierczak B, Dal Cin P, Wanschura S, Borrmann L, Fusco A, Van den Berghe H, Bullerdiek J. HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors. Genes Chromosomes Cancer. 1998 Dec;23(4):279-85. PMID: #9824199#