pleomorphic rhabdomyosarcoma
Anaplastic rhabdomyosarcoma, or pleomorphic rhabdomyosarcoma, is the least common of all subtypes.
Pleomorphic rhabdomyosarcoma most often occurs in patients aged 30-50 years. It is rarely observed in children.
Anaplastic rhabdomyosarcoma is defined by large, lobate hyperchromatic nuclei and multipolar mitotic figures.
Molecular biology
PAX3-FOXO1A fusion gene (as in alveolar rhabdomyosarcoma) (#12550764#)
Genic amplification
FGFR1 amplification (8p11 amplification) (#16790082#)
References
Gordon A, McManus A, Anderson J, Fisher C, Abe S, Nojima T, Pritchard-Jones K, Shipley J. Chromosomal imbalances in pleomorphic rhabdomyosarcomas and identification of the alveolar rhabdomyosarcoma-associated PAX3-FOXO1A fusion gene in one case. Cancer Genet Cytogenet. 2003 Jan 1;140(1):73-7. PMID: #12550764#