cystic neuroblastoma
Cystic neuroblastoma (CN) is an unusual variant of neuroblastoma characterized by a grossly visible cyst(s) and almost always distinctive microcysts on light microscopy. Rarely, CN will appear solid grossly, but microcystification will be present.
Synopsis
favorable stage
stroma-poor with low or intermediate mitotic-karyorhectic indices
favorable biologic markers
- aneuploidy
- absence of N-myc amplificatio
- absence of chromosome 1p deletions
clinical outcome excellent
See also
neuroblastic tumors
neuroblastomas
- bilateral cystic neuroblastoma
References
Kozakewich HP, Perez-Atayde AR, Donovan MJ, Fletcher JA, Estroff JA, Shamberger RC, Diller L. Cystic neuroblastoma: emphasis on gene expression, morphology, and pathogenesis. Pediatr Dev Pathol. 1998 Jan-Feb;1(1):17-28. PMID: #10463268#