Definition: Synovial sarcoma (SS) is a translocation-associated sarcoma characterized by SS18-SSX1/2 fusion. It presents most often in the extremities of young adults. While SS regularly occurs in the pleuropulmonary parenchyma, the mediastinum is an exceedingly rare primary site.
Mediastinal SS is a rare and aggressive malignancy most common in patients younger than 50 years. Most are monophasic and reach large size before detection. Poorly differentiated morphology is common.
SS should (...)
Home > F. Pathology by regions > Thorax > Mediastinum
Mediastinum
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mediastinal synovial sarcoma
26 March 2018 -
mediastinal low-grade extraskeletal osteosarcoma
19 March 2018Low-grade extraskeletal osteosarcoma of the mediastinum; mediastinal LGESOS
Definition: Extraskeletal osteosarcoma (ESOS) is a rare soft tissue sarcoma, typically characterized by a bone-producing neoplasm. Low-grade extraskeletal osteosarcoma (LGESOS) is an extremely rare soft tissue tumor, and patients with LGESOS tend to have a better prognosis.
Open references
Low-grade extraskeletal osteosarcoma of the mediastinum: report of a case and review of literature. Int J Clin Exp Pathol. (...) -
mediastinal pericytic tumors
18 March 2018mediastinal perivascular tumors
Less than ten cases of glomus tumour, including a single malignant variant, have been described in the mediastinum until 2015. All cases were located in the posterior or superior compartments of the mediastinum in young or middle-aged females. The single malignant case, which resulted in this patient’s death, occurred in a 74-year-old female.
Pain and dyspnea or cough were presenting symptoms. All benign cases were successfully treated by surgery without (...) -
mediastinal leiomyosarcoma
18 March 2018Definition: Mediastinal leiomyosarcoma is a very rare tumour with less than 40 cases until 2015.
Mediastinal leiomyosarcoma occurs in adult patients (26–88 years) of either sex.
A disproportionate number of cases arise in the posterior mediastinum, where tumours are often clinically asymptomatic.
Resected tumours measured up to 18 cm, often without clear relationship to neighbouring anatomic structures. In some cases, an origin from major vessels seemed likely, whilst in others, major (...) -
mediastinal leiomyoma
18 March 2018Definition: A mediastinal leiomyoma is a leiomyoma arising in the mediastinum.
To qualify as a primary mediastinal leiomyoma, tumours should arise from the somatic soft tissue of the mediastinum, whilst esophageal and large vessel primaries should be excluded.
If these criteria are applied, primary mediastinal leiomyoma is very rare with approximately 20 reported cases in the literature in 2015.
Mediastinal leiomyoma is twice as common in females as in males and is mainly seen in the (...) -
mediastinal mesenchymal tumors
18 March 2018Definition: Mediastinal mesenchymal tumors are mesenchymal tumors arising in the mediastinum.
Examples
mediastinal smooth muscle tumors
Open references
Mesenchymal tumours of the mediastinum—part I
Michael A. den Bakker, Alexander Marx, Kiyoshi Mukai, Philipp Ströbel
Virchows Arch. 2015; 467: 487–500. Published online 2015 Sep 10. doi:10.1007/s00428-015-1830-8.
PMCID: PMC4656709
Mesenchymal tumours of the mediastinum—part II
Michael A. den Bakker, Alexander Marx, Kiyoshi Mukai, (...) -
mediastinal tumors
18 March 2018WKP
Definition: Mediastinal tumors are tumors arising in the mediastinum.
The mediastinum is the cavity that separates the lungs from the rest of the chest. It contains the heart, esophagus, trachea, thymus, and aorta. The mediastinum has three main parts: the anterior mediastinum (front), the middle mediastinum, and the posterior mediastinum (back).
The most common mediastinal masses are neurogenic tumors (20% of mediastinal tumors), usually found in the posterior mediastinum , (...) -
mediastinal smooth muscle tumors
18 March 2018Definition: Mediastinal smooth muscle tumors are smooth muscle tumors arising in the mediastinum.
Smooth muscle cell tumours resemble normal smooth muscle and retain many of their immunohistochemical markers. Fewer benign smooth muscle cell tumours (leiomyomas) than malignant smooth muscle tumours (leiomyosarcomas) have been reported in the mediastinum.
Types
mediastinal leiomyoma
mediastinal leiomyosarcoma
Examples
mediastinal mesenchymal (...) -
mediastinal lymphomas
16 June 2017Images
Mediastinal lymphoma causing superior vena cava syndrome amongst other things. https://twitter.com/E_Heidi_Cheek/status/874778314543570944
See also
mediastinal tumors
lymphomas -
mediastinal extramedullary hematopoietic tumor
16 September 2013mediastinal reactive extramedullary hematopoietic tumors; thoracic extramedullary hematopoiesis
"Reactive extramedullary hematopoietic tumors that usually occur in patients with severe chronic anemias.
Patients with extramedullary hematopoietic tumors are characterized by anemia, frequent hepatosplenomegaly and abnormal peripheral blood smears, and may be any age.
The tumors are usually multiple and usually located in the mediastinum or epidural space.
Associations
hereditary (...)