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plasmacytoid dendritic cell
Friday 2 October 2009
CD123-positive plasmacytoid dendritic cells, plasmacytoid dendritic cells; natural interferon−producing cells; plasmacytoid dendritic cells
Definition: Human and mouse plasmacytoid dendritic cells have been shown to correspond to a specialized cell population that produces large amounts of type I interferons in response to viruses, the so-called "natural interferon−producing cells".
As a result, intensive investigation is now focused on the potential functions of plasmacytoid dendritic cells in both innate and adaptive immunity.
Pathology
blastic plasmacytoid dendritic cell neoplasm (BBDCN) (19956058)
Plasmacytoid dendritic cells (PDC) play a crucial role in the initiation of immune responses and activation of T-cells and B-cells.
In primary cutaneous marginal zone B-cell lymphoma (PCMZL) (19718787)
- The detection of larger clusters of PDC in PCMZL provides a useful adjunctive diagnostic marker and suggests a pathogenetically relevant role of these cells in PCMZL.
- The occurrence of PDC could explain the high number of T-cells typically found in PCMZL.
- PCMZL can be consider as a unique and potentially antigen-driven neoplasm with PDC, T-cells, and B-cells as the constitutive tumor components.
Links
Plasmacytoid dendritic cells in immunity (PDF)
Immunohistochemical Discrimination of Plasmacytoid Dendritic Cells (PDF)
Reviews
Plasmacytoid dendritic cells in immunity: Review - Nature Immunology 5, 1219 - 1226 (2004)
References
Cutaneous Manifestations of Blastic Plasmacytoid Dendritic Cell Neoplasm-Morphologic and Phenotypic Variability in a Series of 33 Patients. Cota C, Vale E, Viana I, Requena L, Ferrara G, Anemona L, Metze D, Fink-Puches R, Wiesner T, Cerroni L. Am J Surg Pathol. 2009 Dec 2. PMID: 19956058
CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone B-cell lymphoma: diagnostic and pathogenetic implications. Kutzner H, Kerl H, Pfaltz MC, Kempf W. Am J Surg Pathol. 2009 Sep;33(9):1307-13. PMID: 19718787
CD4(+) CD56(+) lineage-negative malignancies are rare tumors of plasmacytoid dendritic cells. Reichard KK, Burks EJ, Foucar MK, Wilson CS, Viswanatha DS, Hozier JC, Larson RS. Am J Surg Pathol. 2005 Oct;29(10):1274-83. PMID: 16160468