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pemphigus foliaceus
Saturday 4 February 2006
Pathogeny
The relevant antibody in pemphigus foliaceus reacts with desmoglein-1 (DSG1), which is expressed in the uppermost epidermal layers, thus correlating with the characteristic subcorneal plane of blister formation in this variant.
See also
pemphigus vulgaris
References
Payne AS, Hanakawa Y, Amagai M, Stanley JR. Desmosomes and disease: pemphigus and bullous impetigo. Curr Opin Cell Biol. 2004 Oct;16(5):536-43. PMID: 15363804
Moll R, Moll I. Epidermal adhesion molecules and basement membrane components as target structures of autoimmunity. Virchows Arch. 1998 Jun;432(6):487-504. PMID: 9672190