fetal thrombotic vasculopathy

Thrombi in the fetal circulation of the placenta cause a pattern of clustered fibrotic villi called fetal thrombotic vasculopathy (FTV), which has been associated with serious injuries to neonates, especially brain injuries.

Synopsis

 fetal somatic thrombi (37.5%)

• cerebral thrombi or infarcts (three cases)
• renal thromboemboli (three cases)
• pulmonary thromboemboli (two cases)

 severe perinatal liver disease

• perinatal Budd-Chiari syndrome
  cholestasis
  bile duct proliferation
  portal fibrosis

See also

 fetal thrombophilia
 inherited or acquired thrombophilic state

References

 Ariel I, Anteby E, Hamani Y, Redline RW. Placental pathology in fetal thrombophilia. Hum Pathol. 2004 Jun;35(6):729-33. PMID: 15188139

 Kraus FT, Acheen VI. Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol. 1999 Jul;30(7):759-69. PMID: 10414494

 McDonald DG, Kelehan P, McMenamin JB, Gorman WA, Madden D, Tobbia IN, Mooney EE. Placental fetal thrombotic vasculopathy is associated with neonatal encephalopathy. Hum Pathol. 2004 Jul;35(7):875-80. PMID: 15257552

 Dahms BB, Boyd T, Redline RW. Severe perinatal liver disease associated with fetal thrombotic vasculopathy. Pediatr Dev Pathol. 2002 Jan-Feb;5(1):80-5. PMID: 11815872