Home > D. General pathology > CD18 deficiency
CD18 deficiency
MIM.600065 21q22.3
Tuesday 18 October 2005
Autosomal recessive disorder - Leukocyte adhesion deficiency type 1.
Synopsis
recurrent bacterial infections
impaired pus formation
impaired wound healing
abnormal adhesion-dependent functions of granulocytes, monocytes, and lymphocytes
infection of umbilical cord stump
omphalitis
gingivitis (periodontosis)
Associations
systemic juvenile rheumatoid arthritis
Biology
leukocyte cell adhesion molecule defect
reduced neutrophil phagocytic and respiratory burst
response to bacteria and yeast
reduced adherance to various substances
reduced migration into infection sites