foreign body reaction

See also : foreign-body giant cell

Definition: The foreign body granuloma is a response of biological tissue to any foreign material in the tissue. Tissue-encapsulation of an implant is part of this. An infection around a splinter is part of this, too.

The presence of the implant changes the healing response, and this is called the foreign-body reaction (FBR).

FBR consists of: protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis.

Examples of foreign body

 wood
 glass
 surgical material
 talc in intravenous drug use
 beryllium

Localization

 lung
 skin

• dermal foreign body granuloma

 joints

• synovial foreign body reaction

Digital slides

 UI:872 - Foreign body granuloma (Foreign body reaction)

Images

 Foreign-body giant cell reaction to suture in lower lip

• https://twitter.com/reportesVilla/status/736325167270514688

 Foreign body giant cells chewing up lamellar keratin strands from a ruptured cyst.

• https://twitter.com/SGottesmanMD/status/949353841799122944

Synopsis

 granulomatous inflammation
 foreign body giant cells
 foreign body splinter
 marked fibrosis and scaring
 remnants of the foreign body surrounded by multinucleated giant cells

Etiology

 foreign body penetration
 cholesterol deposits (cholesterol crystals, cholesterol clefts)
 tissular calcifications (calcium deposits)

See also

 chronic inflammation