Home > D. Systemic pathology > Hematopathology > Bone marrow > acute monocytic leukemia
acute monocytic leukemia
Sunday 21 November 2004
Digital case
JRC:10576 : Monocytic leukemia
Cytogenetics
t(9;22)(q34;q11) translocation (16518848) t(10;11)(p13;q14) translocation (16518848)
Gene overexpression
HOXA9,
- HOXA9 is essential to myeloid differentiation and is expressed in PICALM-MLLT10 and MLL-rearranged acute leukemias.
See also
leukemias
References
Sindt A, Deau B, Brahim W, Staal A, Visanica S, Villarese P, Rault JP, Macintyre E, Delabesse E. Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. Genes Chromosomes Cancer. 2006 Jun;45(6):575-82. PMID: 16518848