Home > G. Tumoral pathology > tissular specificity of tumors
tissular specificity of tumors
Monday 5 July 2004
Mechanisms
fusion gene in which the promoter region of a first gene is juxtaposed to the entire coding sequence of a second gene that is subsequently overexpressed in specific tissue
- Exemple: fusion gene in which the osteoblast cadherin 11 gene (CDH11) promoter region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence on 17p13 with USP6 overexpression in aneurysmal bone cyst (15026324)