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Ischemia

Tuesday 17 June 2003

Digital cases

 Case 77 (HPC:77) : Hepatic ischemia in prematurity
 Case 159 (HPC:159) : Myocardial infarction

Definition: Ischemia is a loss of blood supply from impeded arterial flow or reduced venous drainage in a tissue. Ischemia compromises the supply not only of oxygen, but also of metabolic substrates, including glucose (normally provided by flowing blood).

Localization

 cerebral ischemia
 limbs ischemia
 myocardic ischemia
 visceral ischemia

See also

 ischemic necrosis

References

 Liang D, Dawson TM, Dawson VL. What have genetically engineered mice taught us about ischemic injury? Curr Mol Med. 2004 Mar;4(2):207-25. PMID: 15032714

 Salvemini D, Cuzzocrea S: Superoxide, superoxide dismutase and ischemic injury. Curr Opin Investig Drugs 3:886, 2002.

 Sheridan AM, Bonventre JV: Cell biology and molecular mechanisms of injury in ischemic acute renal failure. Curr Opin Nephral Hypertens 9:427, 2000.