Home > A. Molecular pathology > MADH7
MADH7
MIM.602932
Tuesday 20 April 2004
Smad7 is a major inhibitory regulator of transforming growth factor (TGF)-beta signaling. Smad7 expression is induced by TGF-beta itself and other signaling pathways, indicating a key role for Smad7 in feedback or cross-talk control of TGF-beta signaling.
Pathology
Smad7 is a crucial regulator of TGF-beta activity in human diseases.
aberrant expression of Smad7 in inflammatory bowel disease aberrant expression of Smad7 in scleroderma.
References
Nakao A, Okumura K, Ogawa H. Smad7: a new key player in TGF-beta-associated disease. Trends Mol Med. 2002 Aug;8(8):361-3. PMID: 12127716