bone tumors

Semiological classification

 bone-forming tumors of bones
 cartilage-forming tumors of bones
 fibrous tumors of bones (fiber-forming osseous tumors)
 nonmatrix-producing bone tumors

Developped semiological classification

 bone-forming tumors of bones

• Reactive or Post-Traumatic Lesions that may be Mistaken for Malignant Tumors
  • Florid Reactive Periostitis
  • Subungual (Dupuytren) Exostosis
  • Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion)

• Benign Tumors
  • Bone Island (Solitary Enostosis)
  • Osteopoikilosis
  • Melorheostosis
  • Osteopathia Striata (Voorhoeve’s Disease)
  • Surface Osteomas of the Cranium, Facial Bones, and Other Bones
  • Osteoid Osteoma
  • Osteoblastoma

• Malignant Tumors
  • Osteosarcoma (Osteogenic Sarcoma)
  • Paget’s Sarcoma
  • Radiation Sarcoma

 cartilage-forming tumors of bones

• Benign Tumors
  • Osteochondroma (Osteocartilaginous Exostosis)
  • Multiple Osteochondromas (Hereditary Multiple Osteocartilaginous Exostoses)
  • Dysplasia Epiphysealis Hemimelica (Osteochondroma of the Epiphysis; Trevor’s Disease)
  • Enchondromatosis (Ollier’s Disease)

• Benign Neoplasms
  • Enchondroma
  • Juxtacortical Chondroma (Periosteal Chondroma)
  • Chondroblastoma
  • Chondromyxoid Fibroma
  • Fibromyxoma, 416

• Malignant Neoplasms
  • Intramedullary Chondrosarcoma
  • Mesenchymal Chondrosarcoma
  • Clear Cell Chondrosarcoma
  • Chordoma

 fibrous tumors of bones (fiber-forming osseous tumors)

• Reactive or Post-Traumatic Tumors
  • Periosteal ‘Desmoid’ Tumors
  • Nonossifying Fibroma (Fibrous Cortical Defect; Benign Fibrous Histiocytoma)

• Benign Neoplasms
  • Fibrous Dysplasia (Fibro-Osseous Dysplasia; Fibro-Osseous Lesion)
  • Liposclerosing Myxofibrous Tumor
  • Osteofibrous Dysplasia (Differentiated Adamantinoma)
  • Desmoplastic Fibroma, 441

• Malignant Neoplasms
  • Fibrosarcoma
  • Malignant Fibrous Histiocytoma
  • Adamantinoma of Long Bones

 nonmatrix-producing bone tumors

• Benign Nonmatrix-Producing Bone Tumors
  • Reactive or Post-Traumatic Tumors
    • Epidermoid Inclusion Cyst
    • Ganglion Cyst of Bone
    • Unicameral Bone Cyst (Solitary Cyst; Simple Bone Cyst)

• Benign Tumors Including Neoplasms
  • Aneurysmal Bone Cyst
  • Giant Cell Reparative Granuloma (Solid Aneurysmal Bone Cyst)
  • Hemangioma of Bone
  • Skeletal Hemangiomatosis/Lymphangiomatosis (Cystic Angiomatosis of Bone, Lymphangiectasis of Bone)
  • Eosinophilic Granuloma (Langerhans’ Cell Histiocytosis)
  • Lipid Granulomatosis of Bone (Chester-Erdheim Disease)
  • Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease),
  • Systemic Mastocytosis
  • Giant Cell Tumor
  • Lipoma of Bone

• Malignant Nonmatrix-Producing Bone Tumors
  • Ewing’s Sarcoma (Primitive Neuroectodermal Tumor)
  • Immunohematopoietic Neoplasms
    • Primary Non-Hodgkin’s Lymphoma
    • Hodgkin’s Disease
    • Leukemia
    • Multiple Myeloma
    • Solitary (Localized) Myeloma (Plasmacytoma)

• • Vascular Neoplasms
    • Well-Differentiated Endothelial Neoplasms
    • Poorly Differentiated Endothelial Neoplasms
    • Hemangiopericytoma

• • Metastatic Cancer

WHO classification 2002

 cartilage tumors of bone
 osteogenic tumors of bone
 fibrogenic tumors of bone
 fibrohistiocytic tumors of bone
 Ewing sarcoma of bone/primitive neuroectodermal tumor of bone
 hematopoietic tumors of bone
 giant cell tumor of bones
 notochordal tumors of bone
  vascular tumors of bone
 smooth muscle tumors of bone
 lipogenic tumors of bone
 neural tumors of bone
 miscellaneous tumors of bone

Differential diagnosis

 osseous tumor-like conditions

Links

 bonetumor.org
 Benign, Malignant and Metastatic Bone Tumors by Daria Brooks, MD; James Jelinek, MD; Dhruv Kumar, MD at WCI, DC

See also

 osseous anomalies / bone anomalies / bone lesions

References

 Abdul-Karim FW, Bauer TW, Kilpatrick SE, Raymond KA, Siegal GP; Association of Directors of Anatomic and Surgical Pathology. Recommendations for the reporting of bone tumors. Association of Directors of Anatomic and Surgical Pathology. Hum Pathol. 2004 Oct;35(10):1173-8. PMID: 15492983