adrenal cortical adenoma

Definition: Adrenocortical adenomas are a functionally heterogeneous group of benign neoplasms that can differentiate toward any of the cortical layers.

Images

 Nuclear pseudoinclusions in adrenal cortical adenoma

• https://twitter.com/a_sleeping_dog/status/766154834185641984

 Adrenal cortical adenoma

• https://twitter.com/a_sleeping_dog/status/750195822805983232
• https://twitter.com/a_sleeping_dog/status/766149574696108032
• https://twitter.com/AssaadAM/status/715046004542869504

Digital cases

 JRC:14604 : Adrenal cortical adenoma.
 JRC:14612 : Atypical adrenal cortical adenoma.
 JRC:18772 : Adrenal cortical adenoma.
 JRC:18775 : Adrenal cortical adenoma, left, with Cushing’s syndrome (F 43 y/o).
 JRC:18766 : Adenoma, adrenal cortex; secreting aldosterone (F, 46 y/o)

These tumors can be associated with the overproduction of glucocorticoids (Cushing syndrome), androgenic or estrogenic steroids (adrenogenital syndromes), or mineralocorticoids (Conn syndrome).

Mixed syndromes can develop, and cortical adenomas without apparent functional activity are relatively common.

Types

 Cushing syndrome-associated adrenocortical adenoma
 aldosterone-producing adrenocortical adenoma
 virilizing adrenocortical adenoma

Predisposition

 Carney triad (MIM.604287) (23681078)

See also

 adrenocortical tumors
 Conn syndrome

References

 Adrenal Cortical Adenoma: The Fourth Component of the Carney Triad and an Association With Subclinical Cushing Syndrome. Carney JA, Stratakis CA, Young WF Jr. Am J Surg Pathol. 2013 May 15. PMID: 23681078

 Wieneke JA, Thompson LD, Heffess CS. Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients. Am J Surg Pathol. 2003 Jul;27(7):867-81. PMID: 12826878