Home > E. Pathology by systems > Digestive system > Liver and pancreatobiliary system > Pancreas > pancreatic acinar cell carcinoma
pancreatic acinar cell carcinoma
Tuesday 9 March 2004
Acinar cell carcinoma of pancreas
| PO |
Images
pancreatic acinar cell carcinoma
- https://twitter.com/KUSAURAP/status/578069039697633280
- https://twitter.com/RMeunierMD/status/584066836867735553
- https://twitter.com/KUSAURAP/status/738741327391653888
- https://twitter.com/mreyesm/status/713393408094683136
- https://twitter.com/KUSAURAP/status/681722974743834624
- https://twitter.com/CaDxPath/status/847705934612672516
Synopsis
monotounous acini with mild atypia.
Differential diagnosis
pancreatic endocrine tumors
solid-pseudopapillary tumors
pancreatoblastoma
ductal adenocarcinoma
acinar cell adenoma
focal acinar cell transformation
microglandular carcinoma
Variants
pancreatic mixed acinar-endocrine carcinoma (15290275)
pancreatic acinar cell carcinomas with prominent ductal differentiation (mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma (20182344)
acinar cell carcinoma of the pancreas metastatic to the ovary (18724247)
Immunochemistry
IHC stains are BCL10, trypsin. Chromogrnain -.
Molecular biology
frequent allelic loss on chromosome 11p (50%)
alterations in the APC/beta-catenin pathway (23.5%)
- beta-catenin mutations
- APC truncations
no K-ras mutation (8031464)
Allelotype: 11072247
| 1p36.31 | 4q26-31.1 | 17p13 | 11q | 13q | 15q15-22.1 | 3q | 6q | 8q | 18q | 21q |
| >70% | >70% | >70% | 60%-70% | 60%-70% | 60%-70% | 50%-60% | 50%-60% | 50%-60% | 50%-60% | 50%-60% |
CGH (comparative genomic hybridization) (10862035)
| gains | 1q42 | 12p11.2 | Xq12-21 |
| losses | 16p13.2-p13.1 | 16q23 |
See also
pancreatic tumors
pancreatic acinar tumors
References
Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. Stelow EB, Shaco-Levy R, Bao F, Garcia J, Klimstra DS. Am J Surg Pathol. 2010 Apr;34(4):510-8. PMID: 20182344
Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. Vakiani E, Young RH, Carcangiu ML, Klimstra DS. Am J Surg Pathol. 2008 Oct;32(10):1540-5.PMID: 18724247
