motor proteins

Proteins participating in many different intracellular transport systems.

Members

 kinesins (KIFs)
 dyneins
 myosins: MYOs, MYHs, MYLs

Pathology (diseases linked to motor proteins)

 kinesin KIF1B: mutations in the Charcot-Marie-Tooth disease type 2A
 dyneins: mutations in the immotile cilia syndrome
 unconventional myosins: hereditary human hearing impairment

See also

 microtubule-dependent protein motors

Animations

 Axonal transport: A movie from J Cell Biol

References

 Hirokawa N, Takemura R. Molecular motors and mechanisms of directional transport in neurons. Nat Rev Neurosci. 2005 Mar;6(3):201-14. PMID: 15711600

 Mallik R, Gross SP. Molecular motors: strategies to get along. Curr Biol. 2004 Nov 23;14(22):R971-82. PMID: 15556858

 Holzbaur EL. Motor neurons rely on motor proteins. Trends Cell Biol. 2004 May;14(5):233-40. PMID: 15130579

 Gunawardena S, Goldstein LS. Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease. J Neurobiol. 2004 Feb 5;58(2):258-71. PMID: 14704957

 Hirokawa N, Takemura R. Biochemical and molecular characterization of diseases linked to motor proteins. Trends Biochem Sci. 2003 Oct;28(10):558-65. PMID: 14559185

 Kamal A, Goldstein LS. Principles of cargo attachment to cytoplasmic motor proteins. Curr Opin Cell Biol. 2002 Feb;14(1):63-8. PMID: 11792546

 Goldstein LS. Molecular motors: from one motor many tails to one motor many tales. Trends Cell Biol. 2001 Dec;11(12):477-82. PMID: 11719052

 Terada S, Hirokawa N. Moving on to the cargo problem of microtubule-dependent motors in neurons. Curr Opin Neurobiol. 2000 Oct;10(5):566-73. PMID: 11084318