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high-grade oncocytic tumour
Thursday 7 January 2021
HOT ; eosinophilic vacuolated tumor (EVT)
Images
https://twitter.com/gcai1978/status/1346915046186770439
Synopsis
morphology : pleomorphic cells
IHC : CD117+, CK7 only rare cells, cathepsin-K +
Often TSC/MTOR mutations
Associations
tuberous sclerosis complex / TSC (31002177)
Differential diagnosis
HOT should be considered as an emerging renal entity because it does not meet the diagnostic criteria for other recognized eosinophilic renal tumors, such as oncocytoma, chromophobe renal cell carcinoma (RCC), TFE3 and TFEB RCC, SDH-deficient RCC, and eosinophilic solid and cystic RCC.
See also
cathepsin-K
Paywall references
"High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases. PMID : 30232607