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MMR-deficient colorectal carcinoma
Friday 7 September 2018
Mismatch Repair Deficient Colorectal Carcinomas.
Mismatch repair-deficient tumors frequently show high-grade histologic features, yet the World Health Organization classifies them as low grade to reflect their favorable prognosis compared with mismatch repair-proficient cancers.
Intestinal-type colorectal adenocarcinomas are graded based on extent of glandular differentiation, although mucinous, signet-ring cell, and solid cancers are, by convention, classified as high grade.
Paywall references
Tumor Grade is Prognostically Relevant Among Mismatch Repair Deficient Colorectal Carcinomas. Johncilla M, Chen Z, Sweeney J, Yantiss RK. Am J Surg Pathol. 2018 Aug 31. doi : 10.1097/PAS.0000000000001145 PMID: 30179899