Mallory bodies

Definition: Subtype of intermediate filament inclusions seen in hepatocytes in a variety of liver diseases and in pneumocytes.

Mallory bodies contain keratin-8 (KRT8) and keratin-18 (KRT18).

Images

 Mallory body is an inclusion found in the cytoplasm of liver cells, are damaged intermediate filaments. Frank Burr Mallory described in 1911.

• https://twitter.com/ilovepathology1/status/899739901121486848

 amiodarone-associated hepatic anomalies

• https://twitter.com/CArnold_GI/status/735956508492615682

 Mallory bodies in alveolar pneumocytes (chemo-related lung injury)

• https://twitter.com/smlungpathguy/status/719648662180274177

Etiology

 alcoholic liver disease

• alcoholic hepatitis

 drug-associated hepatic anomalies

• amiodarone-associated hepatic anomalies

 primary biliary cirrhosis (PBC)

Immunochemistry

 ubiquitin + (11338474, 2462130)

References

 Fickert P, Trauner M, Fuchsbichler A, Stumptner C, Zatloukal K, Denk H. Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins. J Hepatol 2003;38:387-394.

 Denk H, Stumptner C, Zatloukal K. Mallory bodies revisited. J Hepatol 2000;32:689-702.

 Jensen K, Gluud C. The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey). Hepatology. 1994 Oct;20(4 Pt 1):1061-77. PMID: 7927209

 Worman HJ. Cellular intermediate filament networks and their derangement in alcoholic hepatitis. Alcohol Clin Exp Res. 1990 Dec;14(6):789-804. PMID: 2088113

 French SW. Present understanding of the development of Mallory’s body. Arch Pathol Lab Med. 1983 Sep;107(9):445-50. PMID: 6192789