error minimization

The standard genetic code (SGC) assigns amino acids to codons in such a way that the impact of point mutations is reduced, this is termed ’error minimization’ (EM).

The occurrence of EM has been attributed to the direct action of selection, however it is difficult to explain how the searching of alternative codes for an error minimized code can occur via codon reassignments, given that these are likely to be disruptive to the proteome.

An alternative scenario is that EM has arisen via the process of genetic code expansion, facilitated by the duplication of genes encoding charging enzymes and adaptor molecules. This is likely to have led to similar amino acids being assigned to similar codons.

Strikingly, if during code expansion the most similar amino acid to the parent amino acid, out of the set of unassigned amino acids, is assigned to codons related to those of the parent amino acid, then genetic codes with EM superior to the SGC easily arise.

This scheme mimics code expansion via the gene duplication of charging enzymes and adaptors.

The result is obtained for a variety of different schemes of genetic code expansion and provides a mechanistically realistic manner in which EM has arisen in the SGC. These observations might be taken as evidence for self-organization in the earliest stages of life.

See also

 biophilosophy
 origin of life

References

 The neutral emergence of error minimized genetic codes superior to the standard genetic code. Massey SE. J Theor Biol. 2016 Nov 7;408:237-42. doi : 10.1016/j.jtbi.2016.08.022 PMID: 27544417