Home > E. Pathology by systems > Skin > eccrine spiradenoma
eccrine spiradenoma
Monday 30 May 2016
| PO |
Definition: Spiradenoma forms a firm nodule on the face or upper trunk, and can be painful. The lesion is benign. Histologically it shows nests with two types of cells: small hyperchromatic cells at the periphery and larger and paler cells centrally. There is compact PAS+ eosinophilic basement membrane material and infiltrating lymphocytes.
Images
eccrine spiradenoma
- https://twitter.com/KUSAURAP/status/688570974602575872
- https://twitter.com/drtylerhickey/status/712333119026647041
- https://twitter.com/RyanHickMD/status/709486901367943168
- https://twitter.com/yamahalion/status/665783302213603329
- https://twitter.com/DrRMalliah/status/746176832127504384
- https://twitter.com/ASDPTweets/status/667192409256685569
- https://twitter.com/Patholwalker/status/1171683029841895425
- https://twitter.com/Patholwalker/status/1214082547941986304
cystic eccrine spiradenoma
- https://twitter.com/angeldeoromx/status/720434236969197568
- https://twitter.com/dr_schneiderm/status/592856541839097856
eccrine spiradenoma nodule in the subcutis
Synopsis
sharply circumscribed dermal nodule : " blue ball " appearance in dermis
lobular architecture
very cellular / high cellularity
scant cytoplasm
high vascularity
variable lymphocytic infiltrate within lesion / interstitial lymphocytes
hyaline globules
biphasic appearance : light cells and dark cells / basophilic cells
eosinophilic hyaline droplets
presence of ducts / intratumoral ducts
Can occur both separately and in combination with cylindromas
blue nodula formation with peripheral small basaloid cells and larger paler cells centrally
lobulated tumor islands separated by thin fibrous tissue containing blood vessels
Variants
IHC
CK7+ epithelial and p63+ myoepithelial cells
Differential diagnosis
cutaneous lymphadenoma
cutaneous cylindroma
cutaneous metastatic carcinoma
cutaneous synovial sarcoma
cutaneous thymoma
See also
- cutaneous adnexal tumors