gastric inverted hyperplastic polyp

Gastric inverted hyperplastic polyp (IHP) is a rare type of gastric polyp, and is characterized by downward growth of the hyperplastic mucosal components into the submucosa.

The lesions are mainly composed of hyperplastic foveolar-type glands with focal cystic dilatation.

Pyloric type glands, endocrine cells, acinic cell metaplasia, and smooth muscle bundles were also seen as components of the polyp.

Some cases can coexist with multifocal gastritis cystica profunda (GCP) and gastric adenocarcinoma.

Some case exhibit an intermediate form between IHP and GCP.

IHP may be gastritis cystica profunda (GCP) associated with exaggeratedly hyperplastic and metaplastic changes.

Some cases coexist with gastric adenocarcinoma. These facts could lead to further investigate the relation between gastric IHP and carcinoma.

References

 Gastric inverted hyperplastic polyp. Report of four cases and relation to gastritis cystica profunda. Yamashita M, Hirokawa M, Nakasono M, Kiyoku H, Sano N, Fujii M, Koyama T, Yoshida S, Sano T. APMIS. 2002 Oct;110(10):717-23. PMID: 12583438