fibroblastic reticular cell tumor

Fibroblastic reticular cell (FRC) neoplasms, which are one of the histiocyte tumor types, are very rare.

Synopsis

 cytokeratin (CK)-positive FRC neoplasm having features of follicular dendritic cells
 lymph node : multiple nodular aggregations simulating and replacing normal follicles. - The tumor cells have a uniform, large and oval to polygonal shape, abundant cytoplasm, and various sizes of nuclei with central eosinophilic nucleoli and coarse nuclear chromatin.
 They Are positive for CK AE1/AE3+CAM5.2, CK7, tenascin C, l-caldesomone, and CD21, weakly positive for S100, and negative for CD1a.

References

 Cytokeratin-positive Fibroblastic Reticular Cell Tumor With Follicular Dendritic Cell Features: A Case Report and Review of the Literature. Goto N, Tsurumi H, Takami T, Futamura M, Morimitsu K, Takata K, Sato Y, Yoshino T, Adachi S, Saito K, Yamakawa M. Am J Surg Pathol. 2015 Apr;39(4):573-80. doi : 10.1097/PAS.0000000000000362 PMID: 25768257