cutaneous spindle B-cell lymphoma

Cutaneous lymphomas of both B cells and less commonly T cells can exceptionally exhibit spindle-cell morphology.

Less than 30 spindle-cell B-cell lymphomas of the skin have been described, mostly before the adoption of detailed immunohistochemistry, and thus initially interpreted as variants of diffuse large B-cell lymphoma (DLBCL). Furthermore, some authors suggest that cutaneous spindle-cell B-cell lymphomas (cSCBCLs) may behave more aggressively than their conventional morphologic counterparts and may thus merit more aggressive treatment.

However, most cSCBCLs are variants of low-grade B-cell lymphomas of follicle center cell origin and not intermediate-grade variants of DLBCL.

References

 Cutaneous Spindle B cell Lymphomas are Follicular: Most Are Neoplasms of Follicular Center Cell Origin. Charli-Joseph Y, Cerroni L, LeBoit PE. Am J Surg Pathol. 2015 Jan 28. PMID: 25634743