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synovial chondromatosis

Tuesday 15 October 2013

synovial osteochondromatosis, primary synovial osteochondromatosis, synovial chondrometaplasia; Reichel’s syndrome or Reichel-Jones-Henderson syndrome, named after Friedrich Paul Reichel, Hugh Toland Jones and Melvin Starkey Henderson.

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Definition: Synovial chondromatosis is a disease affecting the synovium, a thin flexible membrane around a joint.

Synopsis

 chondroid metaplasia in chronic synovitis

Images

 Synovial Chondromatosis: hyaline nodules; myxoid degeneration; +/- hypercellularity; binucleation

 intra-articular synovial chondromatosis

 macroscopy

 radiology

Synopsis

 Numerous round osteocartilaginous nodules cover a thickened synovial surface or float freely within joint space.
 Cartilage cells with variable atypia or binucleated forms within synovium ;
 clusters of chondrocytes are often arranged in lobules;
 no underlying arthritis
 hyaline nodules
 myxoid degeneration
 +/- hypercellularity
 binucleation

Differential diagnosis

 cartilaginous loose bodies : more common, but associated with arthritis
 chondrosarcoma: not within a joint, no characteristic clustering pattern, marked myxoid change, spindling of nuclei
 injury-related soft-tissue calcification
 arborescent lipoma with osseous metaplasia
 neuropathic arthropathy or osteochondritis dissecans : no lobulation, clustering or atypia
 pigmented villonodular synovitis
 secondary synovial chondrometaplasia due to degenerative joint disease
-synovial vascular malformation

Secondary disease

Associated with degenerative joint disease - growth of fragments of articular cartilage

Initially intrasynovial disease without loose bodies; then intrasynovial proliferation and free loose bodies, then multiple free osteochondral bodies without intrasynovial disease. No atypia.

See also

 chondromatosis
 synovial anomalies