prostatic atypical basal cell hyperplasia

Atypical adenomatous hyperplasia (adenosis) - when seen in a needle biopsy - is one of the most challenging benign mimics of cancer.

Synopsis

 In rare instances, basal cell hyperplasia shows prominent nucleoli. This is referred to as atypical basal cell hyperplasia. In most cases, this is in response to inflammation nearby.
 The immunostain for high molecular weight cytokeratin 34bE12 nicely demonstrates the fragmented basal cell layer in this focus of AAH encountered in a needle biopsy.
 The immunostain for high molecular weight cytokeratin 34bE12 demonstrates fragmented basal cell layer in the previous focus of AAH.
 However, there is a lack of cytologic atypia in AAH at high magnification.

Differential diagnosis

A partially sampled focus of cancer may be mistaken for AAH.

Links

 WebPathology