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chronic myelomonocytic leukemia
Monday 27 August 2012
CMML; CMMOL
Definition: Chronic myelomonocytic leukemia (CMML or CCMOL) is a rare clonal hematopoietic disorder.
Cutaneous CMML tumors
Chronic myelomonocytic leukemia (CMML) can also involve the skin.
A minimal panel of immunohistochemical markers including CD68, CD1a, S100, Langerin, and CD123 is necessary to make the correct classification in this spectrum of cutaneous CMML tumors, in which dendritic cell lineage plays an important role.
Reference
Specific Skin Lesions in Chronic Myelomonocytic Leukemia: A Spectrum of Myelomonocytic and Dendritic Cell Proliferations. A Study of 42 Cases. Vitte F, Fabiani B, Bénet C, Dalac S, Balme B, Delattre C, Vergier B, Beylot-Barry M, Vignon-Pennamen D, Ortonne N, Algros MP, Carlotti A, Samaleire D, Frouin E, Levy A, Laroche L, Theate I, Monnien F, Mugneret F, Petrella T. Am J Surg Pathol. 2012 Sep;36(9):1302-1316. PMID: 22895265