sclerosing mucoepidermoid carcinoma.

Definition: Mucoepidermoid carcinoma (MEC) is the most common primary malignancy in the salivary gland. The rare sclerosing variant of MEC is characterized by dense stromal sclerosis and lymphoplasmacytic infiltrates.

IgG4+ Plasma Cells in Sclerosing Variant of Mucoepidermoid Carcinoma

 IgG4-related sclerosing disease is a recently described syndrome with unique histologic features characterized by intense lymphoplasmacytic infiltrates with increased IgG4 plasma cells and dense stromal sclerosis.
 The disease spectrum frequently includes benign inflammatory diseases, such as autoimmune pancreatitis, cholangitis, and chronic sclerosing sialadenitis (CSS).
 An increased IgG4 plasma cells in sclerosing MEC has been demonstrated. (22743285)
 The association of elevated IgG4 plasma cells with increased fibrosis in the sclerosing variant of MEC suggests a role of IgG4 plasma cells in fibrogenesis and may be a new concept related to sclerosis in cancer.

References

 IgG4+ Plasma Cells in Sclerosing Variant of Mucoepidermoid Carcinoma. Tian W, Yakirevich E, Matoso A, Gnepp DR. Am J Surg Pathol. 2012 Jul;36(7):973-9. PMID: 22743285