SHH-associated medulloblastoma

References

 Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Northcott PA, Hielscher T, Dubuc A, Mack S, Shih D, Remke M, Al-Halabi H, Albrecht S, Jabado N, Eberhart CG, Grajkowska W, Weiss WA, Clifford SC, Bouffet E, Rutka JT, Korshunov A, Pfister S, Taylor MD. Acta Neuropathol. 2011 Aug;122(2):231-40. Epub 2011 Jun 17. PMID: #21681522#

 Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Lee MJ, Hatton BA, Villavicencio EH, Khanna PC, Friedman SD, Ditzler S, Pullar B, Robison K, White KF, Tunkey C, Leblanc M, Randolph-Habecker J, Knoblaugh SE, Hansen S, Richards A, Wainwright BJ, McGovern K, Olson JM. Proc Natl Acad Sci U S A. 2012 May 1. PMID: #22550175#

 Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma. Bhatia B, Potts CR, Guldal C, Choi S, Korshunov A, Pfister S, Kenney AM, Nahlé ZA. Acta Neuropathol. 2012 Apr;123(4):587-600. PMID: #22407012# [Free]

 Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Grammel D, Warmuth-Metz M, von Bueren AO, Kool M, Pietsch T, Kretzschmar HA, Rowitch DH, Rutkowski S, Pfister SM, Schüller U. Acta Neuropathol. 2012 Apr;123(4):601-14. PMID: #22349907# [Free]