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adrenal cortical tumors
Friday 2 March 2012
adrenocortical tumors
Images
Adrenal cortical adenoma and carcinoma
Digital cases
JRC:14604 : Adrenal cortical adenoma.
JRC:14612 : Atypical adrenal cortical adenoma.
JRC:14613 : Adrenal cortical carcinoma (with Cushing syndrome)
JRC:18771 : Adrenal carcinoma (NOS)
JRC:18772 : Adrenal adenoma (NOS).
Types according to grade
adrenal cortical adenoma (ACA )
adrenal cortical carcinoma (ACC )
Types according to secretion
non-secreting adrenocortical tumor
androgens-secreting adrenocortical tumor
aldosterone-secreting adrenocortical tumor
cortisol-secreting adrenocortical tumor
Types according to age
pediatric adrenal cortical tumors
Typing
Weiss Score (WS) system
- The pathologic diagnosis of adrenocortical carcinoma (ACC) still needs to be improved, because the renowned Weiss Score (WS) system has a poor reproducibility of some parameters and is difficult to apply in borderline cases and in ACC variants.
reticulin algorithm (23774167)
- The "reticulin algorithm" (RA) defines malignancy through an altered reticulin framework associated with 1 of the 3 following parameter: necrosis, high mitotic rate, and vascular invasion.
- Reticulin staining is a reliable technique and an easy-to-interpret system in adrenocortical tumors. 23774167)
- It has a high interobserver reproducibility, which supports the notion of using such a method in the proposed 2-step RA approach for ACC diagnosis. 23774167)
LOH
17q22-24 LOH (PRKAR1A locus) (14500362)
Gene mutations
somatic mutations in the PRKAR1A gene (14500362)
References
The Reticulin Algorithm for Adrenocortical Tumor Diagnosis: A Multicentric Validation Study on 245 Unpublished Cases. Duregon E, Fassina A, Volante M, Nesi G, Santi R, Gatti G, Cappellesso R, Dalino Ciaramella P, Ventura L, Gambacorta M, Dei Tos AP, Loli P, Mannelli M, Mantero F, Berruti A, Terzolo M, Papotti M. Am J Surg Pathol. 2013 Jun 14. PMID: 23774167
Adrenocortical Tumors: Improving the Practice of the Weiss System Through Virtual Microscopy: A National Program of the French Network INCa-COMETE. Tissier F, Aubert S, Leteurtre E, Al Ghuzlan A, Patey M, Decaussin M, Doucet L, Gobet F, Hoang C, Mazerolles C, Monges G, Renaudin K, Sturm N, Trouette H, Vacher-Lavenu MC, Viallon V, Baudin E, Bertagna X, Coste J, Libe R. Am J Surg Pathol. 2012 Aug;36(8):1194-1201. PMID: 22790860