urothelial carcinoma in situ

Definition: Carcinoma in situ (CIS), as urothelial dysplasia , is related to recurrence and progression of urothelial carcinoma.

Images

 http://www.webpathology.com/image.asp?n=7&Case;=57

Digital cases

 UI:513 : Urothelial carcinoma (transitional cell carcinoma) in-situ

Types

 papillary urothelial anomalies
 flat urothelial anomalies

Differential diagnosis

 urothelial reactive atypia

• Cis : CK20+, p53+, high Ki67 (11474293, 12640096)
• Aberrant CK20 expression in urothelial cells plus overexpression of p53 and Ki-67 are indicators of dysplastic change in urothelial mucosa. (12640096)

See also

 urothelial carcinoma (transitional cell carcinoma )

• non-invasive urothelial carcinoma
• invasive urothelial carcinoma

Open References

 Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia. Mallofré C, Castillo M, Morente V, Solé M.
Mod Pathol. 2003 Mar;16(3):187-91.
PMID: 12640096 (free)
http://www.nature.com/modpathol/journal/v16/n3/full/3880741a.html

References

 Discriminatory immunohistochemical staining of urothelial carcinoma in situ and non-neoplastic urothelium: an analysis of cytokeratin 20, p53, and CD44 antigens.
McKenney JK, Desai S, Cohen C, Amin MB.
Am J Surg Pathol. 2001 Aug;25(8):1074-8.
PMID: 11474293