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abdominal inflammatory myofibroblastic tumor
Tuesday 21 June 2011
Inflammatory myofibroblastic tumor (IMT) occurring in abdominal location is a rare condition in children.
Inflammatory myofibroblastic tumor (IMT) is a proliferative lesion composed of spindle cells accompanied by inflammatory infiltrate.
Synopsis
infiltrative growth pattern
variable admixture of spindle (myofibroblastic and fibroblastic) cells and
predominantly mononuclear inflammatory cells
possible compact fascicular spindle cell proliferation with collagenized matrix and a distinct focal or sparse inflammatory infiltrate resembling a fibromatosis-like proliferation
possible spindle cells to plump cells in an edematous myxoid background with scattered lymphocytes, plasma cells, eosinophils and small blood vessels, resembling a granulation tissue.
possible foci of necrosis
rare atypical tumor cells
low mitotic index (@<@1/10 HPF-high power fields)
no ganglion-like cells, Reed-Sternberg-like cells or calcification/ossification foci
Immunochemistry
ALK+
Strong diffuse vimentin and focal to diffuse smooth muscle actin was observed in the cytoplasm of spindle cells
focal desmin+
Localization
gastric
hepatic
colonic
splenic adrenal
pancreatic