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giant cell pneumonia
Wednesday 15 December 2010
Digital cases
Case 78 (HPC:78) : Coronavirus giant cell pneumonia
Definition: Giant cell pneumonia is a distinctive and uncommon lesional pattern characterized by interstitial pneumonia and presence of numerous alveolar multinucleated gaint cells.
Syndromal pattern
giant cell interstitial pneumonia
- Warthin-Finkedley cells
Etiology
viral pneumonia
- measles pneumonia (11170972, 10939545, 8191831, 1876472, 3227007)
- VRS pneumonia (3724802, 3838449, 6611144)
- mumps pneumonia (2085116)
- severe acute respiratory syndrome, SARS coronavirus (15765160, 15279629, 12781536)
- varicella zoster pneumonia (VZV infection) (16160838, 2537070)
- parainfluenza virus (12562244, 1650545)
- parainfluenza virus type 3 (3034189, 6265340)
giant cell interstitial pneumonia
- idiopathic
- occupational exposure to hard metals or cobalt
- Langerhans cell histiocytosis (Letterer-Siwe disease) (3618221)
References
Giant cell interstitial pneumonia. Daroca PJ Jr, George WJ. South Med J. 1991 Feb;84(2):257-63. PMID: 1990465
Lung involvement in childhood measles: severe immune dysfunction revealed by quantitative immunohistochemistry. Moussallem TM, Guedes F, Fernandes ER, Pagliari C, Lancellotti CL, de Andrade HF Jr, Duarte MI. Hum Pathol. 2007 Aug;38(8):1239-47. PMID: 17499339
Sudden death in childhood due to varicella pneumonia: a forensic case report with clinical implications. Pfeiffer H, Varchmin-Schultheiss K, Brinkmann B. Int J Legal Med. 2006 Jan;120(1):33-5. PMID: 16160838
Evolution of pulmonary pathology in severe acute respiratory syndrome. Hsiao CH, Wu MZ, Chen CL, Hsueh PR, Hsieh SW, Yang PC, Su IJ. J Formos Med Assoc. 2005 Feb;104(2):75-81. PMID: 15765160
The spectrum of pathological changes in severe acute respiratory syndrome (SARS). Cheung OY, Chan JW, Ng CK, Koo CK. Histopathology. 2004 Aug;45(2):119-24. PMID: 15279629
Lung pathology of fatal severe acute respiratory syndrome. Nicholls JM, Poon LL, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY, Peiris JS. Lancet. 2003 May 24;361(9371):1773-8. PMID: 12781536
Human parainfluenza virus giant cell pneumonia following cord blood transplant associated with pulmonary alveolar proteinosis. Butnor KJ, Sporn TA. Arch Pathol Lab Med. 2003 Feb;127(2):235-8. PMID: 12562244
Unusual presentation of measles giant cell pneumonia in a patient with acquired immunodeficiency syndrome. Okamura A, Itakura O, Yoshioka M, Kubota M, Kikuta H, Kobayashi K. Clin Infect Dis. 2001 Feb 1;32(3):E57-8. PMID: 11170972
Familial cases of severe measles pneumonia. Ito I, Ishida T, Hashimoto T, Arita M, Osawa M, Tsukayama C. Intern Med. 2000 Aug;39(8):670-4. PMID: 10939545
Cytologic diagnosis of measles pneumonia in a bronchoalveolar lavage specimen. A case report. Harboldt SL, Dugan JM, Tronic BS. Acta Cytol. 1994 May-Jun;38(3):403-6. PMID: 8191831
Parainfluenza virus pneumonitis in an adult. Akizuki S, Nasu N, Setoguchi M, Yoshida S, Higuchi Y, Yamamoto S. Arch Pathol Lab Med. 1991 Aug;115(8):824-6. PMID: 1650545
Measles giant cell pneumonia in a child with human immunodeficiency virus infection. Nadel S, McGann K, Hodinka RL, Rutstein R, Chatten J. Pediatr Infect Dis J. 1991 Jul;10(7):542-4. PMID: 1876472
Congenital mumps pneumonia: a rare cause of neonatal respiratory distress. Groenendaal F, Rothbarth PH, van den Anker JN, Spritzer R. Acta Paediatr Scand. 1990 Dec;79(12):1252-4. PMID: 2085116
Giant cell pneumonia caused by varicella zoster virus in a neonate. Saito F, Yutani C, Imakita M, Ishibashi-Ueda H, Kanzaki T, Chiba Y. Arch Pathol Lab Med. 1989 Feb;113(2):201-3. PMID: 2537070
Measles pneumonia in a newborn. Drut R, Drut RM. Pediatr Pathol. 1988;8(5):553-7. PMID: 3227007
Giant cell pneumonia caused by parainfluenza type 3 in a patient with acute myelomonocytic leukemia. Weintrub PS, Sullender WM, Lombard C, Link MP, Arvin A. Arch Pathol Lab Med. 1987 Jun;111(6):569-70. PMID: 3034189
Giant cell pneumonia in Letterer-Siwe disease. Shimizu T, Fukushima N, Ebihara Y, Sata T, Aoyama Y. Acta Pathol Jpn. 1987 Mar;37(3):493-501. PMID: 3618221
Respiratory syncytial viral infection in children with compromised immune function.Hall CB, Powell KR, MacDonald NE, Gala CL, Menegus ME, Suffin SC, Cohen HJ. N Engl J Med. 1986 Jul 10;315(2):77-81. PMID: 3724802
Giant cell pneumonia due to respiratory syncytial virus. Hemming VG, Fischer GW, Prince GA. Arch Pathol Lab Med. 1985 Mar;109(3):213. PMID: 3838449
Giant cell pneumonia due to respiratory syncytial virus. Occurrence in severe combined immunodeficiency syndrome. Delage G, Brochu P, Robillard L, Jasmin G, Joncas JH, Lapointe N. Arch Pathol Lab Med. 1984 Aug;108(8):623-5. PMID: 6611144
Giant cell pneumonia associated with parainfluenza virus type 3 infection. Little BW, Tihen WS, Dickerman JD, Craighead JE. Hum Pathol. 1981 May;12(5):478-81. PMID: 6265340
Measles giant cell pneumonia in childhood leukemia in remission. Tokunaga O, Tanimura A, Morimatsu M, Nakashima T. Acta Pathol Jpn. 1980 May;30(3):483-7. PMID: 6930817