pancreatic acinar cell carcinoma with prominent ductal differentiation

Pancreatic acinar cell carcinomas (ACCs) are clinically and pathologically distinct from pancreatic ductal adenocarcinomas (PDAs). Whereas endocrine differentiation has been well shown in ACCs, significant ductal components are rare.

Despite the early embryologic divergence of acinar and ductal cell lineages, rare pancreatic tumors have both acinar and ductal differentiation, usually predominantly the former. The clinical course is highly aggressive. (20182344)

References

 Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. Stelow EB, Shaco-Levy R, Bao F, Garcia J, Klimstra DS. Am J Surg Pathol. 2010 Apr;34(4):510-8. PMID: 20182344