Home > D. General pathology > Blood and immunity > trisomy-21 associated transient abnormal myelopoiesis
trisomy-21 associated transient abnormal myelopoiesis
Tuesday 9 November 2010
Approximately 10% of DS newborns present with a hematological disorder known as TAM.
Genetic alterations (presence of GATA1 mutations) and morphological and laboratory findings may be the same as typical trisomy 21-associated AML.
In 70-80% of cases, TAM resolves spontaneously over a period of several weeks to 3 months, whilst in the remaining cases a non-transient acute myeloid leukemia, usually of megakaryoblastic type, develops 1 to 3 years later.
Indications for chemotherapy in TAM are not clearly defined.