cryoglobulinemia

Definition: The cryoglobulins are immunoglobulins that precipitate as serum is cooled below core body temperature.1 Precipitation may occur just below 37°C or not until the serum is cooled to near 4°C. Some cryoglobulins precipitate within a few hours and others may take 2-3 days before they precipitate at 4°C, therefore, cryoglobulin determination is made atleast 72 hours after the serum is maintained at 4°C.

Images

 UPMC #593

 in skin vessels

• https://twitter.com/Nathan_E_Lee/status/725787121328349185
• https://twitter.com/Nathan_E_Lee/status/725735772171554816

 cryoglobuliemia-asscociated glomerulonephritis

• https://twitter.com/AnneMillsMD/status/806279450371510272
• https://twitter.com/BethBraunhut/status/856577188140916736

See also

 vasculitis

• vasculitides