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vitamin D deficiency
Tuesday 30 September 2008
In vitamin D deficiency, there is inadequate substrate for the renal hydroxylase, yielding a deficiency of 1,25(OH)2D, and deficient absorption of calcium and phosphorus from the gut, with consequent depressed serum levels of both.
The hypocalcemia activates the parathyroid glands, causing mobilization of calcium and phosphorus from bone.
Simultaneously, the parathyroid hormone (PTH) induces wasting of phosphate in the urine and calcium retention.
Consequently, the serum levels of calcium are normal or nearly normal, but the phosphate is low; hence, mineralization
References
Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. PMID: 17634462