Cowdry type A inclusions

Definition: Large, pink to purple, eosinophilic intranuclear inclusions of nucleic acid and protein seen in cells infected with herpes simplex or varicella-zoster virus.

They contain intact and disrupted virions and push darkly stained host cell chromatin to the edges of the nucleus.

Images

 Herpes Simplex Esophagitis 1 and 3

 Splendid Cowdry type A inclusion body in cutaneous herpes

• https://twitter.com/Tenonhospital/status/794975901549232128

Examples

 HSV infections (Herpes Simplex Virus infection)

• Herpes Simplex Esophagitis 1 and 3 on webpathology

 VZV infections (varicella-zoster virus)

See also

 Cowdry inclusion bodies / Cowdry inclusion body