MAPKKKs
The MAP Kinase kinases (MAPKKs), such as the MKK and MEK kinases, are one step up the MAP kinase cascade, phosphorylating and activating Map kinases. Still higher in the cascade are the MAPKKKs (MAP kinase kinase kinase) such as raf.
The central core of each MAP kinase pathway (MAPKs pathways) is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKKs) phosphorylates and activates a specific MAPK kinase (MAPKKs), which then activates a specific MAPK.
See also
