lobular cholestasis

Synopsis

 hepatocytic cholestasis

• hepatocytic degeneration
• hepatocytic giant cell transformation

 canalicular cholestasis
 cholestaic hepatocytic rosettes
 biliary infarcts

Etiology (exemples)

  bile salt transporter mutations

• Byler disease
• BRIC (benign recurrent intrahepatic cholestasis)

 mitochondriopathies

• Navajo neurohepatopathy

 sepsis-associated cholestasis in systemic sepsis (bacteriemia, septicemia)
 inflammation-associated cholestasis
 sickle cell anemia
 drug hepatotoxicity

 extrahepatic lymphoma
 early large bile-duct obstruction
 hepatic allograft (liver allograft)

• post-transplant bile-flow impairment
• post-transplant rejection (liver allograft rejection)
   drugs (drug-induced cholestasis)
• contraceptive steroids

See also

 Cholestasis

• intra-hepatic cholestasis
  • lobular cholestasis
    • hepatocytic cholestasis
    • canalicular cholestasis