MUC5AC

MUC5AC, with MUC2, represent a subset of gel-forming mucins. MUC5AC is mainly observed in surface mucous cells of the gastric mucosa and respiratory epithelium.

MUC5AC expression in lung cancer has been reported as a marker of poor outcome or in association with mucinous bronchioloalveolar carcinoma (m-BAC).

See also

 mucins (MUCs)

• gel-forming mucins
  • MUC2

 mucinous tumors

• mucinous carcinomas

References

 Divergent Expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in Dysplasia and Intramucosal Adenocarcinomas With Intestinal and Foveolar Morphology: Is This Evidence of Distinct Gastric and Intestinal Pathways to Carcinogenesis in Barrett Esophagus? Khor TS, Alfaro EE, Ooi EM, Li Y, Srivastava A, Fujita H, Park Y, Kumarasinghe MP, Lauwers GY. Am J Surg Pathol. 2012 Mar;36(3):331-342. PMID: 22261707