G. Tumoral pathology

• mantle cell lymphoma
  30 September 2003

  small cell mantle lymphoma
  Definition: Mantle cell lymphoma (MCL) is characterized by the chromosomal translocation t(11;14)(q13;q32), resulting in overexpression of cyclin-D1 (CCND1) in the vast majority of cases.
  Images
  Mantle cell lymphoma with prominent nodular pattern
  https://twitter.com/DanBabuMD/status/759573102007234560
  https://twitter.com/KyleBradleyMD/status/855422646305124352
  Digital cases
  HPC:286 : Nodal mantle cell lymphoma
  HPC:301 : Mantle cell lymphoma of the (...)

• diffuse large B-cell lymphoma
  23 September 2003

  DLBCL
  Definition: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with recognized variability in clinical outcome, genetic features, and cells of origin.
  2 main types :
  Germinal Center B-Cell like DLBCL / GCB-DLBCL
  Activated B-cell like DLBCL / ABC-DLBCL
  The greatest difference resided between distinct populations of germinal centre (GC) cell tumours; the first being CD10-, Bcl-6+, MUM-1- and the second CD10+ Bcl-6+ MUM-1+. The former group displayed median (...)

• neuroblastoma
  19 July 2003

  neuroblastomas

• tumorigenesis
  13 July 2003

  carcinogenesis, oncogenesis, tumoral transformation ; tumorigenicity
  Definition: Tumorigenesis is a collection of complex genetic diseases characterized by multiple defects in the homeostatic mechanisms that regulate cell growth, proliferation and differentiation.
  Cancer is caused by uncontrolled proliferation and the inappropriate survival of damaged cells, which results in tumour formation. Cells have developed several safeguards to ensure that cell division, differentiation and death (...)

• mesenchymal tumors
  14 June 2003

  mesenchymal tumor
  Definition : Tumors of mesenchyme.
  Classification
  benign mesenchymal tumors
  malignant mesenchymal tumors (sarcomas )
  Types
  adipocytic tumors
  cartilaginous tumors
  fibrous tumors , fibroblastic tumors , myofibroblastic tumors
  osseous tumors
  vascular tumors
  Localization
  soft tissue tumors
  bone tumors
  mesenchymal tumors of the lower genital tract
  digestive mesenchymal tumors
  Molecular types
  NTRK-rearranged mesenchymal tumors (...)

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