ureteropelvic junction obstruction

Ureteropelvic junction obstruction (UPJO) constitutes a significant cause of morbidity in children and exists in a wide range of severity and clinical manifestations.

The cause of UPJO remains largely unknown except for a small group, in which crossing vessels have been considered etiological.

Types

 unilateral pelviureteric junction obstruction
 bilateral pelviureteric junction obstruction

Synopsis

 renal multicystic obstrcutive dysplasia

Genetics

 Locus 6p (#1634233#)

• t(6;19)(p21;q13.1) with CDC5L rearrangement (#9598309#)

Etiology

 crossing vessels
 urothelial mucosal malformation (#16808629#)

References

 Huang WY, Olumi AF, Rosen S. Urothelial mucosal malformation: a rare cause for ureteropelvic junction obstruction. Pediatr Dev Pathol. 2006 Jan-Feb;9(1):72-4. PMID: #16808629#