spindle cell hemangioma

Definition: Spindle cell haemangioendothelioma is an entirely benign, non-recurring lesion which has been renamed "spindle cell hemangioma".

Images

 Spindle cell hemangioma

• https://twitter.com/histiocytosisX/status/715931392580927488
• https://twitter.com/rlhutton/status/864217351474081792

Similarly, it is now appreciated that as many as 20–30% of epithelioid haemangioendotheliomas may give rise to distant metastases (albeit the rate is lower in cytologically bland examples) and hence these tumours have been redesignated as malignant.

Intermediate vascular tumours are now subcategorized into locally aggressive and rarely metastasizing subsets.

Associations

 Maffucci syndrome
 varicose veins
 congenital lymphedema

Differential diagnosis

 Kaposi sarcoma
 angiosarcomas

Molecular Pathology

 IDHs mutations : IDH1 and IDH2 somatic mutations in :

• glial tumors
• spindle cell hemangioma

See also

  vascular tumors ( endothelial cell tumors )

References

 The evolving classification of soft tissue tumours: an update based on the new WHO classification. Fletcher CD. Histopathology. 2006 Jan;48(1):3-12. PMID: 16359532