acantholysis

Definition: Acantholysis is a disruption of the epidermal squamous epithelium. The desmosomal connections between the epithelial cells are destroyed. As a result the cells separate and become round.
It is a lack of cell adhesion).

Synopsis

 acantholytic keratinocytes

Etiology : some examples of acantholytic anomalies

 Darier’s disease ; acantholytic dyskeratosis / acantholysis

• https://twitter.com/jotacegepat/status/676241199934648321
• https://twitter.com/JMGardnerMD/status/1590026649826983937

 In grover disease / Transient acantholytic dermatosis

• https://twitter.com/Valdebran/status/709244174738989056
• https://twitter.com/JMGardnerMD/status/1612094316213665795

 acanthotic squamous cell carcinoma

• https://twitter.com/LilDocLiz1/status/795981076388782080
• https://twitter.com/RikiSotillo/status/856441641716129792

 pemphigus
 cutaneous viral infections

• HSV infections / herpes simplex infections (HSV1 and HSV2)
• varicella zoster infection / zona / herpes zoster infection

References

 Dhitavat J, Fairclough RJ, Hovnanian A, Burge SM. Calcium pumps and keratinocytes: lessons from Darier’s disease and Hailey-Hailey disease. Br J Dermatol. 2004 May;150(5):821-8. PMID: 15149492