translocation-associated soft tissue tumors

Exemples

 alveolar rhabdomyosarcoma

• t(2;13)(q35;q14) (PAX3-FOXO1A)
• t(1;13)(p36;q14) (PAX7-FOXO1A)

 myxoid liposarcoma

• t(12;16)(q13;p11) (FUS-DDIT3)
• t(12;22)(q13;q12) (EWSR1-DDIT3)

 congenital fibrosarcoma and cellualr mesoblastic nephroma

• t(12;15)(p13;q26) (ETV6-NTRK3)

 dermatofibrosarcoma protuberans/giant cell fibroblastoma:

• t(17;22)(q22;q13) (COL1A1-PDGFB)

 alveolar soft part sarcoma

• t(X;17)(p11;q25) (TFE3-ASPL)

 synovial sarcoma

• t(X;18)((p11.2;q11.2) (SS1B-SSX1; SS1B-SSX2; SS1B-SSX4)

 Ewing sarcoma/Primitive neuroectodermal tumor

• t(11;22)(q24;q12) (EWS-FLI1)
• t(21;22)(q22;q12) (EWS-ERG) (ERG at 21q22)
• t(7;22)(p22;q12) (EWS-ETV1) (ETV1 at 7p22)
• t(17;22)(q12;q12) (EWS-E1AF) (E1AF at 17q12)
• t(2;22)((q33;q12) (EWS-FEV) (FEV at 2q23)
• t(22;22)(q1;q12) (EWS-ZSG)

 epithelioid sarcoma

 desmoplastic small round cell tumor

• t(11;22)(p13;q12) (EWS-WT1)

 extraskeletal myxoid chrondrosarcoma

• t(9;22)(q22;q12) (EWS-NR4A3)
• t(9;17)(q22;q11) (RBP56-NR4A3)
• t(9;15)(q22;q21) (TCF12-NR4A3)

 clear cell sarcoma of the soft tissue (soft part melanoma)

• t(12;22)(q13;q12) (EWS-ATF1)

 angiomatoid fibrous histiocytoma

• t(12;16)(q13;p11) (FUS-ATF1)

 endometrial stromal sarcoma

• t(7;17)(p15;q21) (JAZF1-JJAZ1)

 low-grade fibromyxoid sarcoma

• t(7;16)(q33;p11) (FUS-CREB3L2)
• t(11;16)(p11;p11) (FUS-CREB3L1)

 inflammatory myofibroblastic tumor

• t(1;2)(q22;q23) (TPM3-ALK)
• t(2;19)(p23;p13) (TPM4-ALK)
• t(2;17)(p23;p13) (CLTC-ALK)
• t(2;2)(p23;q13) (RANBP2-ALK)

See also

  sarcomas

• non-translocation-associated sarcomas
• translocation-associated sarcomas

References

 Montgomery E, Argani P, Hicks JL, DeMarzo AM, Meeker AK. Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramatically. Am J Pathol. 2004 May;164(5):1523-9. PMID: 15111298