paraganglion in prostate

Paraganglia are usually located external to the prostate near postero-lateral neurovascular bundles. Occasionally, they may be sampled in prostate needle biopsies.

Paraganglia are composed of cells with clear or amphophilic cytoplasm, inconspicuous nucleoli, and a prominent vascular pattern. They are present within smooth muscle bundles away from benign acini. When present in prostate needle biopsies, paraganglia must be distinguished from high-grade adenocarcinoma.

When present in prostate needle biopsies, paraganglia must be distinguished from high-grade prostatic adenocarcinoma.

There can be an admixture of cells with clear and amphophilic cytoplasm.

Prominent vascular pattern, degenerative atypia, lack of immunoreactivity for PSA and PSAP, strong immunoreactivity for neuroendocrine markers (image shows positivity for Synaptophysin), presence of sustentacular cells with S-100 protein favor paraganglion.

Link

 WebPathology 1 : Paraganglion in Prostate Biopsies.
 WebPathology 2 : Paraganglion in Prostate Biopsies.
 WebPathology 3 : Paraganglion in Prostate Biopsies - Immunoreactivity for Synaptophysin.
 WebPathology 4 : Paraganglion in Prostate Biopsies

Reference

 Kawabata K. Arch Pathol Lab Med. 1997;121:515-516.