The normal counterparts of mantle cell lymphoma (MCL) are naive, quiescent B cells that have not been processed through the germinal center (GC). For this reason, although lymphomas arising from GC or post-GC B cells often exhibit plasmacytic differentiation, MCL rarely presents with plasmacytic features.
MCL can present with a PC component that is often clonally related to the lymphoma, representing a rare but unique biological variant of this tumor.
References
Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component. Visco C, Hoeller S, Malik JT, Xu-Monette ZY, Wiggins ML, Liu J, Sanger WG, Liu Z, Chang J, Ranheim EA, Gradowski JF, Serrano S, Wang HY, Liu Q, Dave S, Olsen B, Gascoyne RD, Campo E, Swerdlow SH, Chan WC, Tzankov A, Young KH. Am J Surg Pathol. 2011 Feb;35(2):177-89. PMID: #21263238#
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