high-grade fimbrial-ovarian carcinoma

High-grade endometrioid and serous carcinomas of the ovary and fallopian tube are responsible for the majority of cancer deaths and comprise a spectrum that includes early or localized (tubal intraepithelial carcinoma) and advanced (invasive or metastatic) disease.

Three groups can be defined:
 (1) classic serous carcinomas
 (2) mixed serous and endometrioid carcinomas
 (3) endometrioid carcinomas

Biology

PAX2 and PTEN, in addition to p53 and p16(ink4), comprise a potentially important gene combination in high-grade pelvic carcinogenesis.

References

 High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression. Roh MH, Yassin Y, Miron A, Mehra KK, Mehrad M, Monte NM, Mutter GL, Nucci MR, Ning G, McKeon FD, Hirsch MS, Wa X, Crum CP. Mod Pathol. 2010 Jun 18. PMID: 20562848